7 Comments

Maybe it is too early to extract conclusions about the GLP-1 inhibitors effect as a whole. And they long term effect

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My main concerns with the GLP1s are muscle loss equal to fat loss and eye damage.

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@paddybarrett

What do you think of the notion that seed oils cause some sort of metabolic problem which then drives obesity? It sounds nutty, but I have no way to judge the substance of it. I ask because I've seen the idea posted by rather intelligent people, sharp in their fields but who are not MDs or biologists.

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author

I used to think this was more of an issue but I am less concerned about it today. In fact, I probably never consider it now. Lots of ‘scary’ mechanistic data but when all factors considered I don’t think on its own it’s that much of an issue. You can make a ‘scary’ mechanistic argument for drinking water so you can make it for almost anything. Non issue in my books.

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When you say mechanistic data you mean - ?

I do think that it's easy to be deceived by x after y, therefore x caused y. Assigning effects and causes after both have occurred leaves a ton of room for motivated reasoning.

Anyway, I'm now going to worry less about seed oils. There will be a fashionable now fear to replace them soon enough.

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Great article as always. I don't think we have data yet on the long-term safety of these drugs, although there is plenty of great data on their efficacy. I am optimistically skeptical.

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Great summary, thanks Paddy.

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